The biology in wastewater lagoons can be significantly impacted by toxic substances introduced from illicit drug manufacturing. Surface waters contaminated with amphetamines, and the chemicals used to manufacture them, are known to suppress aquatic life, including microorganisms.1 These chemical compounds inhibit biofilm formation and promote higher abundance of species equipped to survive in toxic environments. Microorganisms that can maintain cellular function in the presence of toxic waste exclude many of the essential biota needed for efficient wastewater processing. These impacts can be applied to wastewater systems that are suffering from drug related toxic hits. The following case study describes the process of restarting the biology in a lagoon system that was killed off by methamphetamine manufacturing chemicals.